What is the chief and highest end of man?

Answer: Man's chief and highest end is to glorify God[1], and fully to enjoy him forever.[2]

1. Rom. 11:36:

   For from him and through him and to him are all things. To him be glory forever. Amen. (ESV)

   
   I Cor. 10:31:

   So, whether you eat or drink, or whatever you do, do all to the glory of God. (ESV)

   
   
2. (Psa. 73:24-28)

   You guide me with your counsel,
   and afterward you will receive me to glory.
   Whom have I in heaven but you?
   And there is nothing on earth that I desire besides you.
   My flesh and my heart may fail,
   but God is the strength of my heart and my portion forever.
   
   For behold, those who are far from you shall perish;
   you put an end to everyone who is unfaithful to you.
   But for me it is good to be near God;
   I have made the Lord God my refuge,
   that I may tell of all your works.(ESV)

From the Westminster Larger Catechism.